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이동순
 
의사명 이동순 교수 / 李東順 / DONG SOON LEE
세부전공 혈액학, 분자세포유전학


학력
기 간 학 력
1992. 3 ~ 1994. 2 서울대학교 대학원 의학박사(1994)
1983. 3 ~ 1985. 2 서울대학교 대학원 의학석사(1985)
1978. 3 ~ 1982. 2 서울대학교 의과대학 의학과/의학사(1982)

경력 및 연수
기 간 경력 및 연수
2003 국가지정연구실 Molecular Imaging Laboratory
2002. 5 ~ 2004. 7 서울대학교 의과대학 연구부 연구부학장보
1998. 3 ~ 현재 서울대학교 의과대학 전임강사/조교수/부교수/교수
1991. 3 ~ 1998. 2 원자력병원/과장
1986. 3 ~ 1991. 2 부천세종병원/과장

학회활동
기 간 학회활동
2010 ~ 현재 대한혈액학회 학술이사
2010 ~ 2011 Korean Society of Laboratory Hematology 대한진단혈액연구회장
2008 ~ 현재 International Journal of Hematology 잡지 Editorial Board
2006 Marquis WHO‘s Who Invitation
2004 ~ 2006 Korean Society of Clinical Pathology 대한진단검사의학회 혈액위원장
2004 ~ 2006 Ministry of Health and Science Early Detection of Cancer 위원
2003 ~ 2006 Korean Association Medicine 대한의학회 학술위원
2003 ~ 2005 Korean Society of Laboratory Hematology 대한진단혈액연구회 학술이사
2002 ~ 현재 중앙약사심의위원회 위원
2002 Korean Society of Thrombosis &Hemostasis 대한지혈혈전학회 재무이사

주요저서
저서명 출판사명 출판연도 공동저자
Encyclopedia of Medical Genomics and Proteomics Chapter: PML/RARA and RARA FISH in Follow-Up of Acute Promyelocytic Leukemia Original Publication Date: 09 December 2004 Last Updated: 23 April 2007      
Handbook on Microchip Methods in Diagnostics, Chapter: “Bio-cell Chip Fabrication and Applications”   2008  
chapter: Cytogenetic Chnages of Hematologic MalignanciesTextbook of Hematology   2006  
혈액학 대한혈액학회편 2006 공동집필
chapter: Fluorescent In Situ Hybridization in Hematologic Malignancies   2000  
Medical Postgraduates Chapter: Molecular Cytogenetic Changes in Hematologic MalignancyTextbook of Clinical Pathology   2000  

주요논문
논문명 발표지 발표년월 공동연구자
8p11 myeloproliferative syndrome with BCR-FGFR1 rearrangement presenting with T-lymphoblastic lymphoma and bone marrow stromal cell proliferation. [Epub ahead of print] Leuk Res. 2011 Jan 14. Seon Young Kim Bora Oh Cha Ja She Hyun Kyung Kim Yoon Kyung Jeon Myung-Geun Shin Sung-Soo Yoon Dong Soon Lee.
Stochastic acquisition of a stem cell-like state and drug tolerance in leukemia cells stressed by radiation. 93(1):27-35 Int J Hematol. 2011 Jan Lee GY, Shim JS, Cho B, Jung JY, Lee DS, Oh IH.
Increased Copy Number of the Interleukin-6 Receptor Gene Is Associated with Adverse Survival in Multiple Myeloma Patients Treated with Autologous Stem Cell Transplantation. : 1-11 Biol Blood Marrow Transplant 2011 Seon Young Kim,1,* Hyun Jung Min,2,* Hyun Kyung Park,3 Bora Oh,2 Tae Young Kim,2 Cha Ja She,1 Sang Mee Hwang,1 Miyoung Kim,1 Hyun Kyung Kim,1 Inho Kim,4 Sung-Soo Yoon,4 Seonyang Park,4 Byoung Kook Kim,4 Jae Hoon Lee,4 Dong Soon Lee,1,2 The Korea Multiple Myeloma Working Party (KMMWP).
Bortezomib, doxorubicin, and dexamethasone combination therapy followed by thalidomide and dexamethasone consolidation as a salvage treatment for relapsed or refractory multiple myeloma: analysis of efficacy and safety.? Page : 905-12 Ann Hematol. 2010 Sep Lee SS, Suh C, Kim BS, Chung J, Joo YD, Ryoo HM, Do YR, Jin JY, Kang HJ, Lee GW, Lee MH, Shim H, Kim K, Yoon SS, Bang SM, Kim HY, Lee JJ, Park J, Lee DS, Lee JH.
Establishment of a new Glivec-resistant chronic myeloid leukemia cell line, SNUCML-02, using an in vivo model.?Page : 773-81 Exp Hematol. 2010 Sep Park J, Kim KI, Koh Y, Won NH, Oh JM, Lee DS, Kim BK, Ahn KS, Yoon SS.?
Hypoplastic myelodysplastic syndrome (h-MDS) is a distinctive clinical entity with poorer prognosis and frequent karyotypic and FISH abnormalities compared to aplastic anemia (AA).?Page : 1344-50 Leuk Res. 2010 Oct? Koh Y, Lee HR, Song EY, Kim HK, Kim I, Park S, Park MH, Kim BK, Yoon SS, Lee DS.
Prognosis of secondary acute myeloid leukemia is affected by the type of the preceding hematologic disorders and the presence of trisomy 8. 1037-45 Jpn J Clin Oncol?ISSN 2010 Nov Koh Y, Kim I, Bae JY, Song EY, Kim HK, Yoon SS, Lee DS, Park SS, Park MH, Park S, Kim BK.
Clinical course of non-severe aplastic anemia in adults. Page : 770-5 Int J Hematol. 2010 Jun Kwon JH, Kim I, Lee YG, Koh Y, Park HC, Song EY, Kim HK, Yoon SS, Lee DS, Park SS, Shin HY, Park S, Park MH, Ahn HS, Kim BK.
Circulating hepatocyte growth factor as an independent prognostic factor of disseminated intravascular coagulation. Page : e285-93   2010 Jun Chung S, Kim JE, Kim JY, Lee DS, Han KS, Kim HK.
The relationship between the presence of chromosomal instability and prognosis of squamous cell carcinoma of the lung: fluorescence in situ hybridization analysis of paraffin-embedded tissue from 47 Korean patients. Page : 863-7 Korean Med Sci. 2010 Jun Yoo JW, Seo KW, Jang SJ, Oh YM, Shim TS, Kim WS, Lee DS, Lee SD, Choi CM.
Cytogenetic features of 5q deletion and 5q- syndrome in myelodysplastic syndrome in Korea; marker chromosomes proved to be chromosome 5 with interstitial deletion by fluorescence in situ hybridization. Page : 193-202 Cancer Genet Cytogenet. 2010 Dec Lee HR, Oh B, Hong DS, Zang DY, Yoon HJ, Kim HJ, Kim I, Ahn JS, Cheong JW, Lee KA, Cho KS, Lee MH, Bang SM, Kim TY, Yun YM, Min YH, Lee YK, Lee DS.
Multiple myeloma in Korea: past, present, and future perspectives. Experience of the Korean Multiple Myeloma Working Party. 92:52? Int J Hematol. 2010 Jae Hoon Lee, Dong Soon Lee,?Je Jung Lee,?Yoon Hwan Chang,?Jong Youl Jin, Deog-Yeon Jo,?Soo Mee Bang,?Hyo Jung Kim,?Jin Seok Kim,?Kihyun Kim, Hyeon Seok Eom,?Chang Ki Min,?Sung Soo Yoon,?Sun Hee Kim,?Cheolwon Suh, Kyung Sam Cho,?the Korean Multiple Myeloma Working Party (KMMWP)
Bortezomib, thalidomide, dexamethasone induction therapy followed by melphalan, prednisolone, thalidomide consolidation therapy as a first line of treatment for patients with multiple myeloma who are non-transplant candidates: results of the Korean Multiple Myeloma Working Party (KMMWP). 89:489?497 Ann Hematol. 2010 Hyeon-Seok Eom & Yeo-Kyeoung Kim & Joo-Seop Chung & Kihyun Kim & Hyo Jung Kim & Ho Young Kim & Jong-Youl Jin & Young-Rok Do & Suk-Joong Oh & Cheolwon Suh & Chu-Myong Seong & Chul Soo Kim & Dong Soon Lee & Jae Hoon Lee.
Molecular Cytogenetic Analysis in Korean Patients with Waldenstrom’s Macroglobulinemia. Cancer Genet Cytogenet 2010 Bang SM, Seo JW, Park KU, Kim SJ, Kim K, Kim SH, Cho SR, Kim HC, Song J, Kim JS, Kim KH, Lee JH, Lee JJ, Shin MG, Suh C, Chi HS, Oh DY, Won JH, Kim HJ, Yoon SS, Lee DS.
Homozygous deletion of CDKN2A (p16, p14) and CDKN2B (p15) genes is a poor prognostic factor in adult but not in childhood B-lineage acute lymphoblastic leukemia: a comparative deletion and hypermethylation study. Cancer Genet Cytogenet. 2009 Kim M, Yim SH, Cho NS, Kang SH, Ko DH, Oh B, Kim TY, Min HJ, She CJ, Kang HJ, Shin HY, Ahn HS, Yoon SS, Kim BK, Shin HR, Han KS, Cho HI, Lee DS.
Natural polyphenols antagonize the antimyeloma activity of proteasome inhibitor bortezomib by direct chemical interaction. Br J Haematol. 2009 Kim TY, Park J, Oh B, Min HJ, Jeong TS, Lee JH, Suh C, Cheong JW, Kim HJ, Yoon SS, Park SB, Lee DS.
Concurrent langerhans cell histiocytosis and B-lineage lymphoid proliferation in the bone marrow. Korean J Lab Med. 2009 Kim M, Kang HJ, Shin HY, Ahn HS, Lee DS.
p15INK4b methylation correlates with thrombocytopenia, blast percentage, and survival in myelodysplastic syndromes in a dose dependent manner: Quantitation using pyrosequencing study. Leuk Res. Sep 24. [Epub ahead of print] 교신 2009 Kim M, Oh B, Kim SY, Park HK, Hwang SM, Kim TY, She CJ, Yang I, Yoon SS, Yoon JH, Lee DS.
Chromosomal instability is a risk factor for poor prognosis of adenocarcinoma of the lung: Fluorescence in situ hybridization analysis of paraffin-embedded tissue from Korean patients. Lung Cancer. 2009 Choi CM, Seo KW, Jang SJ, Oh YM, Shim TS, Kim WS, Lee DS, Lee SD.
Investigation of bone marrow involvement in malignant lymphoma using fluorescence in situ hybridization: possible utility in the detection of micrometastasis. Cancer Genet Cytogenet 2008;186:1-5 2008년 Huh HJ, Min HC, Cho HI, Chae SL, Lee DS.
Protective role of CYP1A1 * 2A in the development of multiple myeloma. Acta Haematol 2008;119:60-4 2008년 Kang SH, Kim TY, Kim HY, Yoon JH, Cho HI, Yoon SS, Kang DH, Suh CW, Lee JH, Lee DS.
Lineage switch from acute myeloid leukemia to biphenotypic acute leukemia with acquisition of Philadelphia chromosome. Cancer Genet Cytogenet 2008;184:124-6 2008년 Lee HR, Kang SH, Kang HJ, Shin HY, Ahn HS, Kim HK, Park MH, Cho HI, Lee DS.
IgH gene rearrangements are associated with hyperdiploid multiple myeloma in Korean cases: a fluorescence in situ hybridization study. Cancer Genet Cytogen 2007;172(2):172-3 2007년 Moon HW, Cho HI, Kang SH, Kim TY, Min HC, Oh BR, Yoon SS, Lee DS.
Application of high throughput cell array technology to FISH: investigation of the role of deletion of p16 gene in leukemias. J Biotechnol 2007;127(3):355-60 2007년 Lee DS, Lee JH, Min HC, Kim TY, Oh BR, Kim HY, Lee JY, Lee CK, Chun HG, Kim HC.
Lee DS. MTHFR 677CC/1298CC genotypes are highly associated with chronic myelogenous leukemia: a case-control study in Korea. Leuk Res 2007;31(9):1213-7 2007년 Moon HW, Kim TY, Oh BR, Min HC, Cho HI, Bang SM, Lee JH, Yoon SS,
Incidence of submicroscopic deletions vary according to disease entities and chromosomal translocations in hematologic malignancies: investigation by fluorescence in situ hybridization. Cancer Genet Cytogenet. 2007;175(2):166-8 2007년 Moon HW, Chang YH, Kim TY, Oh BR, Min HC, Kim BK, Ahn HS, Cho HI, Lee DS.
Fluorescence in situ hybridization (FISH) using snap frozen buffy coat. Ann Clin Lab Sci 2007;37(1):85-8 2007년 Min HJ, Lee J, Choi JE, Shin S, Lee DS.
Korean patients with chronic lymphocytic leukemia show the similar types of chromosomal aberrations as those in Europe and North America. Leuk Res 2006;30(6):695-9 2006년 Chang YH, Park J, Kim HC, Chun HK, Kim YR, Kim M, Han K, Lee JH, Lee KH, Cho HI, Lee YS, Lee DS.
Identification of 13q deletion, trisomy 1q and IgH rearrangement as the most frequent chromosomal changes found in Korean patients with multiple myeloma. Cancer Genet Cytogent 2006;168(2):124-32 2006년 Bang SM, Kim YR, Cho HI, Chi HS, Seo EJ, Park CJ, Yoo SJ, Kim HC, Chun HG, Min HC, Oh BR, Kim TY, Lee JH, Lee DS.
Tumor necrosis factor alpha promoter polymorphism associated with increased susceptibility to secondary hemophagocytic lymphohistiocytosis in the Korean population. Cytokine 2006;36(1-2):45-50 2006년 Chang YH, Lee DS, Jo HS, Cho SI, Yoon HJ, Shin S ,Yoon JH, Kim HY, Hong YJ, Hong SI, Cho HI.
Deletion of any part of the BCR or ABL gene on the derivative chromosome 9 is a poor prognostic marker in chronic myelogenous leukemia. Cancer Genet Cytogent 2006;166(1):65-73 2006년 Lee YK, Kim YR, Min HC, Oh BR, Kim TY, Kim YS, Cho HI, Kim HC, Lee YS, Lee DS.
Therapeutic use of granulocyte-colony stimulating factor could conceal residual malignant cells in patients with AML1/ETO+ acute myelogenous leukemia. Leukemia 2006;20(8):1408-13 2006년 Moon HW, Shin S, Kim HY, Kim YR, Cho HI, Yoon SS, Park S, Kim BK, Chun H, Kim HC, Park CJ, Min YH, Lee DS.
Interpretation of submicroscopic deletions of the BCR or ABL gene should not depend on extra signal-FISH: problems in interpretation of submicroscopic deletion of the BCR or ABL gene with extra signal-FISH. Genes Chromosomes Cancer 2005;43(1):37-44 2005년 Kim YR, Cho HI, Yoon SS, Park S, Kim BK, Lee YK, Chun H, Kim HC, Lee DS.
Genesis of derivative chromosome 9 deletions in chronic myeloid leukemia. Genes Chromosomes Cancer 2005;43(2):225 2005년 Lee DS.
The presence of TEL/AML1 rearrangement and cryptic deletion of the TEL gene in adult acute lymphoblastic leukemia (ALL). Cancer Genet Cytogenet 2005;162(2):176-8 2005년 Lee DS, Kim YR, Cho HK, Lee CK, Lee JH, Cho HI.
The role of fluorescence in situ hybridization (FISH) for monitoring hematologic malignancies with BCR/ABL or ETO/AML1 rearrangement: a comparative study with FISH and G-banding on 919 consecutive specimens of hematologic maliancies. Cancer Genet Cytogen 2004 2004년 Lee DY, Cho HI, Kang YH, Yun SS, Park SY, Lee YS, Kim Y, Lee DS.
Concurrent p16 methylation pattern as an adverse prognostic factor in multiple myeloma: a methylation-specific polymerase chain reaction study using two different primer sets. 90(1):73-9. Ann Hematol. 2011 Jan Park G, Kang SH, Lee JH, Suh C, Kim M, Park SM, Kim TY, Oh B, Min HJ, Yoon SS, Yang IC, Cho HI, Lee DS; Korean Multiple Myeloma Working Party (KMMWP).
Impact of cytokine gene polymorphisms on risk and treatment outcomes of aplastic anemia. Ann Hemato. 2010 Oct 16 Lee YG, Kim I, Kim JH, Bae JY, Kwon JH, Shin DY, Lee JE, Song EY, Kim HK, Yoon SS, Park SS, Lee DS, Han KS, Park MH, Hong YC, Park S, Kim BK.
p15INK4b methylation correlates with thrombocytopenia, blast percentage, and survival in myelodysplastic syndromes in a dose dependent manner : quantitation using pyrosequencing study. 718-22 Leuk Res. 2010 Jun Kim M, Oh B, Kim SY, Park HK, Hwang SM, Kim TY, She CJ, Yang I, Yoon SS, Yoon JH, Lee DS.
Evaluation of the TEST 1 erythrocyte sedimentation rate system and intra- and inter-laboratory quality control using new latex control materials. Page : 1043-8 Clin Chem Lab Med. 2010 Jul? Cha CH, Cha YJ, Park CJ, Kim HK, Cha EJ, Kim DH, Honghoon, Jung JS, Kim MJ, Jang S, Chi HS, Lee DS.


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